Sampayo, R. G., Sakamoto, M., Wang, M., Kumar, S., & Schaffer, D. V. (2023). “Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases.” Proceedings of the National Academy of Sciences of the United States of America, 120(22). https://doi.org/10.1073/PNAS.2219854120. View PDF
Baek, J., Kumar, S., Schaffer, D.V., & Im, S.G. (2022). “N-Cadherin adhesive ligation regulates mechanosensitive neural stem cell lineage commitment in 3D matrices”. Biomaterials Science, 10(23), 6768–6777. https://doi.org/10.1039/D2BM01349E. View PDF
Qiao EL, Kumar S, Schaffer DV. Mastering their own fates through the matrix. Nat Mater. 2019 Aug; 18(8):779-780. doi: 10.1038/s41563-019-0429-x. PubMed PMID: 31332317. View PDF
Muckom R, McFarland S, Yang C, Perea B, Gentes M, Murugappan A, Tran E, Dordick JS, Clark DS, Schaffer DV. High-throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate. Biotechnol Bioeng. 2019 Jan; 116(1):193-205. doi: 10.1002/bit.26815. Epub 2018 Nov 6. PubMed PMID: 30102775; PubMed Central PMCID: PMC6289657. View PDF
Nierode GJ, Gopal S, Kwon P, Clark DS, Schaffer DV, Dordick JS. High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture. Biotechnol Bioeng. 2019 Jan; 116(1):168-180. doi: 10.1002/bit.26839. Epub 2018 Oct 27. PubMed PMID: 30229860; PubMed Central PMCID: PMC6289706. View PDF
Sun S, Schaffer DV. Corrigendum to “Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits” [Curr. Opin. Neurobiol. 50 (2018) 163-170]. Curr Opin Neurobiol. 2018 Dec; 53:220. doi: 10.1016/j.conb.2018.08.005. Epub 2018 Sep 5. PubMed PMID: 30196036. View PDF
Adil MM, Schaffer DV. Cheaper and less variable expansion. Nat Biomed Eng. 2018 Mar; 2(3):144-145. doi: 10.1038/s41551-018-0209-y. PubMed PMID: 31015716. View PDF
Adil MM, Schaffer DV. hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial. Curr Protoc Stem Cell Biol. 2018 Feb 28; 44:2D.21.1-2D.21.17. doi: 10.1002/cpsc.47. PubMed PMID: 29512105. View PDF
Day TP, Byrne LC, Flannery JG, Schaffer DV. Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. Methods Mol Biol. 2018; 1715:239-249. doi: 10.1007/978-1-4939-7522-8_17. PubMed PMID: 29188518. View PDF
Halperin SO, Tou CJ, Wong EB, Modavi C, Schaffer DV, Dueber JE. CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window. Nature. 2018 Aug; 560(7717):248-252. doi: 10.1038/s41586-018-0384-8. Epub 2018 Aug 1. PubMed PMID: 30069054. View PDF
Chen, S. Y.S. Na, M.E. Todhunger, S. Hsiao, A.W. Bremer, O.J. Scheideler, P.R. Bomdica, M.M. Haharbiz, Z.J. Gartner, D.V. Schaffer (2016) “Interrogating Stem Cell Fate Decisions with High-throughput Arrays of Cellular Communities.” View PDF
Tervo, D.G.R., B-Y. Hwang, S. Viswanathan, T. Gaj, M. Lavzin, K.D. Ritola, S. Lindo, S. Michael, E.P. Kuleshova, D. Ojala, C-C. Huang, C.R. Gerfen, J. Schiller, J.T. Dudman, A.W. Hantman, L.L. Looger, D.V. Schaffer (co-corresponding author), and A.Y. Karpova (2016) “A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.” , 92:372-382 (PMID 27720486). View PDF
Bugaj, L.J., D. P. Spelke, C.K. Mesuda, M. Varedi, R.S. Kane, and D.V. Schaffer (2015)”Regulation of Endogenous Transmembrane Receptors Through Optogenetic Cry2 Clustering.” Nature Communications. View PDF
Kotterman, M.A. and D.V. Schaffer (2014) “Engineering Adeno-Associated Viruses for Clinical Gene Therapy.” Nature Reviews Genetics, 15:445-451 (PMID 24840552). View PDF
Shapiro, M.G., R.M. Ramirez, L.J. Sperling, G. Sun, A. Pines, D.V. Schaffer, and V.S. Bajaj (2014) “Genetically Encoded Reporters for Hyperpolarized Xenon.” , 6(7):629-34 (PMID: 24950334). View PDF
Hughes, A.J., D.P. Spelke, Z. Xu, C-C. Kang, D.V. Schaffer (co-corresponding author), and A.E. Herr (2014) “Single-cell Western Blotting.” , 11:749-755 (PMID 24880876). View PDF
Shapiro, M., P. Goodwill, A. Neogy, M. Yin, F. Foster, D.V. Schaffer, and S. Conolly (2014) “Biogenic Gas Nanostructures as Ultrasonic Molecular Reporters.” , 9:311-316 (PMID 24633522). View PDF
Lei, Y. and D.V. Schaffer (2013) “A Fully Defined and Scalable 3D Culture System for Human Pluripotent Stem Cell Expansion and Differentiation.” , 110:E5039-5048 (PMID 24248365). View PDF
Downing, T.L., J. Soto, C. Morez, T. Houssin, A. Fritz, F. Yuan, J. Chu, S. Patel, D.V. Schaffer, and S. Li (2013) “Biophysical Regulation of Epigenetic State and Cell Reprogramming.” , 12:1154-1162 (PMID 24141451). View PDF
Dalkara, D., L.C. Byrne, R.R. Klimczak, M. Visel, L. Yin, W.H. Merigan, J.G. Flannery, and D.V. Schaffer (2013) “In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer-Retinal Gene Delivery from the Vitreous.” , 5:189ra76 (PMID 23761039). View PDF
Conway, A., T. Vazin, D.P. Spelke, N.A. Rode, K.E. Healy, R.S. Kane, and D.V. Schaffer (2013) “Multivalent Ligands to Control Stem Cell Behaviour in Vitro and in Vivo.” , 8:831-838 (PMID 24141540). View PDF
Bugaj, L.J, A.T Choksi, C.K. Mesuda, R.S. Kane, and D.V. Schaffer (2013) “Optogenetic Protein Clustering and Signaling Activation in Mammalian Cells.” , 10:249-252. View PDF
Ashton, R.S., A. Conway, C. Pangarkar, J. Bergen, K-I. Lim, P. Shah, M. Bissell, and D.V. Schaffer (2012) “Astrocytes Regulate Adult Hippocampal Neurogenesis Through Ephrin-B Signaling.” , 15:1399-1406 (PMID: 22983209). View PDF
Dickinson, B.C., J. Peltier, D. Stone, D.V. Schaffer (co-corresponding author), and C.J Chang (2011) “Nox2 Redox Signaling Maintains Essential Cell Populations in the Brain.” , 7:106-112 (PMID 21186346). View PDF
Lim, K-I., R.R. Klimczak, J.H. Yu, and D.V. Schaffer (2010) “Specific Insertions of Zinc Finger Domains into Gag-Pol Yields Engineered Retroviral Vectors with Selective Integration Properties.” , 107:12475-12480 (PMID 20616052). View PDF
Excoffon, K.J., J.T. Koerber, D.D. Dickey, M. Murtha, S. Keshavjee, B.K. Kaspar, J. Zabner, and D.V. Schaffer (2009) “Directed Evolution of Adeno-Associated Virus to an Infectious Respiratory Virus.” Proceedings of the National Academy of Sciences USA, 106:3865-3870 (PMID 19237554). View PDF
Koerber, J.T., N. Maheshri, B.K. Kaspar, and D.V. Schaffer (2006) “Construction of Diverse Adeno-Associated Viral Libraries for Directed Evolution of Enhanced Gene Delivery Vehicles.” Nature Protocols, 1:701-706. View PDF
Maheshri, N., J.T. Koerber, B. Kaspar, and D.V. Schaffer (2006) “Directed Evolution of Adeno-Associated Virus Yields Enhanced Gene Delivery Vectors.” Nature Biotechnology, 24:198-204. View PDF
Weinberger, L.S., J.C. Burnett, J.E. Toettcher, A.P. Arkin, and D.V. Schaffer (2005) “Stochastic Gene Expression in a Lentiviral Feedback Loop: HIV-1 Tat Expression Drives Phenotypic Diversity.” Cell, 122:169-182. View PDF
Zhu, D., Schieferecke, A. J., Lopez, P. A., & Schaffer, D. v. (2021). “Adeno-Associated Virus Vector for Central Nervous System Gene Therapy”. Trends in Molecular Medicine, 27(6), 524–537. https://doi.org/10.1016/J.MOLMED.2021.03.010. View PDF
Schaffer, D., & Shvartsman, S. Y. (2018). “Editorial overview: Tissue, cell and pathway engineering”. Current Opinion in Biotechnology, 52, iv–v. https://doi.org/10.1016/J.COPBIO.2018.07.004. View PDF
Gaj., T., B.E. Epstein, and D.V. Schaffer (2016), “Genome Engineering Using Adeno-Associated Virus: Basic and Clinical Research Applications.” The American Society of Gene & Cell Therapy,1-7(PMID 26373345). View PDF
Kotterman, M.A. and D.V. Schaffer (2014) “Engineering Adeno-Associated Viruses for Clinical Gene Therapy.” Nature Reviews Genetics, 15:445-451 (PMID 24840552). View PDF
Bartel, M.A., J.R. Weinstein, and D.V. Schaffer (2012) “Directed Evolution of Novel Adeno-Associated Viruses for Therapeutic Gene Delivery.” Gene Therapy (2012) 19, 19:694-700 (PMID 22402323). View PDF
Asokan, A., D.V. Schaffer, and R.J. Samulski (2012) “The AAV Vector Toolkit: Poised at the Clinical Crossroads.” The American Society of Gene & Cell Therapy, 20:699-708 (PMID 22273577). View PDF
Keung, A.J., S. Kumar, and D.V. Schaffer (2010) “Presentation Counts: Microenvironmental Regulation of Stem Cells by Biophysical and Material Cues.” Annu. Rev. Cell Dev. Biol. 2010. 26:533-556 (PMID 20590452). View PDF
Vazin, T. and D.V. Schaffer (2010) “Engineering Strategies to Emulate the Stem Cell Niche Trends in Biotechnology.” Trends in Biotechnology Vol.28 No.3, 28:117-124 (PMID 20042248). Selected as the Cover Article. View PDF
Zhu, D., Brookes, D. H., Busia, A., Carneiro, A., Fannjiang, C., Popova, G., Shin, D., Donohue, K. C., Lin, L. F., Miller, Z. M., Williams, E. R., Chang, E. F., Nowakowski, T. J., Listgarten, J., & Schaffer, D. v. (2024). Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy. Science Advances, 10(4). https://doi.org/10.1126/SCIADV.ADJ3786 [PDF]
Sampayo, R. G., Sakamoto, M., Wang, M., Kumar, S., & Schaffer, D. V. (2023). “Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases.” Proceedings of the National Academy of Sciences of the United States of America, 120(22). https://doi.org/10.1073/PNAS.2219854120. View PDF
Repina, N., Johnson, H., Bao, X., Zimmerman, J., Joy, D., Bi, S., Kane, R., Schaffer, D.V. (2023). “Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture “. Development. https://doi.org/10.1242/dev.201386. View PDF
Baek, J., Kumar, S., Schaffer, D.V., & Im, S.G. (2022). “N-Cadherin adhesive ligation regulates mechanosensitive neural stem cell lineage commitment in 3D matrices”. Biomaterials Science, 10(23), 6768–6777. https://doi.org/10.1039/D2BM01349E. View PDF
Miller, Z. M., Harper, C. C., Lee, H., Bischoff, A. J., Francis, M. B., Schaffer, D. V., & Williams, E. R. (2022). “Apodization Specific Fitting for Improved Resolution, Charge Measurement, and Data Analysis Speed in Charge Detection Mass Spectrometry”. Journal of the American Society for Mass Spectrometry, 33(11), 2129–2137. https://doi.org/10.1021/JASMS.2C00213/ASSET/IMAGES/LARGE/JS2C00213_0004.JPEG. View PDF
Yang, S. J., O’Donnell, J. T. del B., Giordani, F., Wang, J., Lui, A., Piekarski, D., Irrinki, A., Schaffer, D. V., & Landry, M. P. (2022). “Synaptic scale dopamine disruption in Huntington’s Disease model mice imaged with near infrared catecholamine nanosensors”. BioRxiv, 2022.09.19.508617. https://doi.org/10.1101/2022.09.19.508617. View PDF
Zhu, D., Brookes, D. H., Busia, A., Carneiro, A., Fannjiang, C., Popova, G., Shin, D., Donohue, K. C., Chang, E. F., Nowakowski, T. J., Listgarten, J., & Schaffer, D.V. (2022). “Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy”. BioRxiv, 2021.11.02.467003. https://doi.org/10.1101/2021.11.02.467003. View PDF
Harper, C. C., Miller, Z. M., Lee, H., Bischoff, A. J., Francis, M. B., Schaffer, D. V., & Williams, E. R. (2022). “Effects of Molecular Size on Resolution in Charge Detection Mass Spectrometry”. Analytical Chemistry, 94(33), 11703–11712. https://doi.org/10.1021/ACS.ANALCHEM.2C02572/ASSET/IMAGES/LARGE/AC2C02572_0007.JPEG. View PDF
Louis, B., Tewary, M., Bremer, A. W., Philippeos, C., Negri, V. A., Zijl, S., Gartner, Z. J., Schaffer, D. V., & Watt, F. M. (2022). “A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation”. Acta Biomaterialia, 150, 265–276. https://doi.org/10.1016/J.ACTBIO.2022.07.054. View PDF
Molina, R. S., Rix, G., Mengiste, A. A., Álvarez, B., Seo, D., Chen, H., Hurtado, J. E., Zhang, Q., García-García, J. D., Heins, Z. J., Almhjell, P. J., Arnold, F. H., Khalil, A. S., Hanson, A. D., Dueber, J. E., Schaffer, D. V. , Chen, F., Kim, S., Fernández, L. Á., … Liu, C. C. (2022). “In vivo hypermutation and continuous evolution”. Nature Reviews Methods Primers 2022 2:1, 2(1), 1–22. https://doi.org/10.1038/s43586-022-00119-5. View PDF
Baek, J., Lopez, P. A., Lee, S., Kim, T. S., Kumar, S., & Schaffer, D. V. (2022). “Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment”. Science Advances, 8(15), 4646. https://doi.org/10.1126/SCIADV.ABM4646/SUPPL_FILE/SCIADV.ABM4646_SM.PDF. View PDF
Qiao, E., Schaffer, D.V., & Kumar, S. (2022). “Substrate stress relaxation regulates neural stem cell fate commitment”. Biophysical Journal, 121(3), 420a. https://doi.org/10.1016/J.BPJ.2021.11.655. View PDF
Zhu, D., Johnson, H. J., Chen, J., & Schaffer, D. V. (2022). “Optogenetic Application to Investigating Cell Behavior and Neurological Disease”. Frontiers in Cellular Neuroscience, 16, 4. https://doi.org/10.3389/FNCEL.2022.811493/BIBTEX. View PDF
Öztürk, B. E., Johnson, M. E., Kleyman, M., Turunç, S., He, J., Jabalameli, S., Xi, Z., Visel, M., Dufour, V. L., Iwabe, S., Marinho, F. P., Aguirre, G. D., Sahel, J. A., Schaffer, D. v., Pfenning, A. R., Flannery, J. G., Beltran, W. A., Stauffer, W. R., & Byrne, L. C. (2021). “Scaavengr, a transcriptome-based pipeline for quantitative ranking of engineered aavs with single-cell resolution”. ELife, 10. https://doi.org/10.7554/ELIFE.64175. View PDF
Croze, R. H., Kotterman, M., Burns, C. H., Schmitt, C. E., Quezada, M., Schaffer, D., Kirn, D., & Francis, P. (2021). “Viral Vector Technologies and Strategies: Improving on Nature”. International Ophthalmology Clinics, 61(3), 59. https://doi.org/10.1097/IIO.0000000000000361. View PDF
Barnes, C. R., Lee, H., Ojala, D. S., Lewis, K. K., Limsirichai, P., & Schaffer, D. v. (2021). “Genome-wide activation screens to increase adeno-associated virus production”. Molecular Therapy – Nucleic Acids, 26, 94–103. https://doi.org/10.1016/J.OMTN.2021.06.026. View PDF
Kotterman, M., Beliakoff, G., Croze, R., Vazin, T., Schmitt, C., Szymanski, P., Leong, M., Quezada, M., Holt, J., Barglow, K., Hassanipour, M., Schaffer, D., Francis, P., & Kirn, D. (2021). “Directed Evolution of AAV Targeting Primate Retina by Intravitreal Injection Identifies R100, a Variant Demonstrating Robust Gene Delivery and Therapeutic Efficacy in Non-Human Primates”. BioRxiv, 2021.06.24.449775. https://doi.org/10.1101/2021.06.24.449775. View PDF
Zhu, D., Schieferecke, A. J., Lopez, P. A., & Schaffer, D. v. (2021). “Adeno-Associated Virus Vector for Central Nervous System Gene Therapy”. Trends in Molecular Medicine, 27(6), 524–537. https://doi.org/10.1016/J.MOLMED.2021.03.010. View PDF
Lei, R., Akins, E. A., Wong, K. C. Y., Repina, N. A., Wolf, K. J., Dempsey, G. E., Schaffer, D. v., Stahl, A., & Kumar, S. (2021). “Multiwell Combinatorial Hydrogel Array for High-Throughput Analysis of Cell-ECM Interactions”. ACS Biomaterials Science and Engineering, 7(6), 2453–2465. https://doi.org/10.1021/ACSBIOMATERIALS.1C00065/ASSET/IMAGES/LARGE/AB1C00065_0006.JPEG. View PDF
Ramasubramanian, A., Muckom, R., Sugnaux, C., Fuentes, C., Ekerdt, B. L., Clark, D. S., Healy, K. E., & Schaffer, D. v. (2021). “High-Throughput Discovery of Targeted, Minimally Complex Peptide Surfaces for Human Pluripotent Stem Cell Culture”. ACS Biomaterials Science and Engineering, 7(4), 1344–1360. https://doi.org/10.1021/ACSBIOMATERIALS.0C01462/ASSET/IMAGES/LARGE/AB0C01462_0006.JPEG. View PDF
Cabral, K. A., Patterson, D. M., Scheideler, O. J., Cole, R., Abate, A. R., Schaffer, D. v., Sohn, L. L., & Gartner, Z. J. (2021). “Simple, affordable, and modular patterning of cells using DNA”. Journal of Visualized Experiments, 2021(168). https://doi.org/10.3791/61937. View PDF
Rosenbloom, A. B., Tarczynski, M., Lam, N., Kane, R. S., Bugaj, L. J., & Schaffer, D. v. (2020). “β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells”. Proceedings of the National Academy of Sciences of the United States of America, 117(46), 28828–28837. https://doi.org/10.1073/PNAS.2008509117/SUPPL_FILE/PNAS.2008509117.SAPP.PDF. View PDF
Mukherjee, A., Sudrik, C., Hu, Y., Arha, M., Stathos, M., Baek, J., Schaffer, D. v., & Kane, R. S. (2020). “CL6mN: Rationally Designed Optogenetic Photoswitches with Tunable Dissociation Dynamics”. ACS Synthetic Biology, 9(9), 2274–2281. https://doi.org/10.1021/ACSSYNBIO.0C00362/ASSET/IMAGES/LARGE/SB0C00362_0006.JPE. View PDF
Carneiro, A., Lee, H., Lin, L., van Haasteren, J., & Schaffer, D. v. (2020). “Novel Lung Tropic Adeno-Associated Virus Capsids for Therapeutic Gene Delivery”. Human Gene Therapy, 31(17–18), 996–1009. https://doi.org/10.1089/HUM.2020.169/ASSET/IMAGES/LARGE/HUM.2020.169_FIGURE3.JPEG. View PDF
Muckom, R. J., Sampayo, R. G., Johnson, H. J., Schaffer, D. v, Muckom, R. J., Sampayo, R. G., Schaffer, D. v, Johnson, H. J., & Schaffer Graduate Program in Bioengineering, D. v. (2020). “Advanced Materials to Enhance Central Nervous System Tissue Modeling and Cell Therapy”. Advanced Functional Materials, 30(48), 2002931. https://doi.org/10.1002/ADFM.202002931. View PDF
Muckom, R., Bao, X., Tran, E., Chen, E., Murugappan, A., Dordick, J. S., Clark, D. S., & Schaffer, D. v. (2020). “High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates”. Science Advances, 6(32). https://doi.org/10.1126/SCIADV.AAZ1457/SUPPL_FILE/AAZ1457_SM.PDF. View PDF
van Haasteren, J., Li, J., Scheideler, O. J., Murthy, N., & Schaffer, D. v. (2020). “The delivery challenge: fulfilling the promise of therapeutic genome editing”. Nature Biotechnology 2020 38:7, 38(7), 845–855. https://doi.org/10.1038/s41587-020-0565-5. View PDF
Repina, N. A., Johnson, H. J., McClave, T., Kane, R. S., & Schaffer, D. v. (2020). “Protocol to Fabricate Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics”. STAR Protocols, 1(3), 100141. https://doi.org/10.1016/J.XPRO.2020.100141. View PDF
Repina, N. A., McClave, T., Johnson, H. J., Bao, X., Kane, R. S., & Schaffer, D. v. (2020). “Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics”. Cell Reports, 31(10), 107737. https://doi.org/10.1016/J.CELREP.2020.107737. View PDF
Kulkarni, R. U., Gest, A. M. M., Lam, C. K., Raliski, B. K., James, F., Adil, M. M., Schaffer, D. v, Wang, Y., & Miller, E. W. (2020). Computationally Assisted Design of High Signal-to-Noise Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes. https://doi.org/10.26434/CHEMRXIV.12401753.V1. View PDF
Byrne, L. C., Day, T. P., Visel, M., Strazzeri, J. A., Fortuny, C., Dalkara, D., Merigan, W. H., Schaffer, D. v., & Flannery, J. G. (2020). “In vivo–directed evolution of adeno-associated virus in the primate retina”. JCI Insight, 5(10). https://doi.org/10.1172/JCI.INSIGHT.135112. View PDF
Scheideler, O. J., Yang, C., Kozminsky, M., Mosher, K. I., Falcón-Banchs, R., Ciminelli, E. C., Bremer, A. W., Chern, S. A., Schaffer, D. v., & Sohn, L. L. (2020). “Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach”. Science Advances, 6(12), 5696–5714. https://doi.org/10.1126/SCIADV.AAY5696/SUPPL_FILE/AAY5696_SM.PDF. View PDF
Mukherjee, A., Stathos, M. E., Varner, C., Arsiwala, A., Frey, S., Hu, Y., Smalley, D. M., Schaffer, D. v., & Kane, R. S. (2020). “One-pot synthesis of heterodimeric agonists that activate the canonical Wnt signaling pathway”. Chemical Communications, 56(25), 3685–3688. https://doi.org/10.1039/D0CC00920B. View PDF
Kang, P. H., Schaffer, D. v., & Kumar, S. (2020). “Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells”. Molecular Biology of the Cell, 31(5), 386–396. https://doi.org/10.1091/MBC.E19-11-0602/ASSET/IMAGES/LARGE/MBC-31-386-G006.JPEG. View PDF
Kim, S. H., Lee, S., Lee, H., Cho, M., Schaffer, D. v., & Jang, J. H. (2019). AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems. Molecular Therapy – Nucleic Acids, 18, 432–443. https://doi.org/10.1016/J.OMTN.2019.09.015. View PDF
Bao, X., Adil, M. M., Muckom, R., Zimmermann, J. A., Tran, A., Suhy, N., Xu, Y., Sampayo, R. G., Clark, D. S., & Schaffer, D. v. (2019). Gene Editing to Generate Versatile Human Pluripotent Stem Cell Reporter Lines for Analysis of Differentiation and Lineage Tracing. Stem Cells, 37(12), 1556–1566. https://doi.org/10.1002/STEM.3096. View PDF
Qiao EL, Kumar S, Schaffer DV. Mastering their own fates through the matrix. Nat Mater. 2019 Aug; 18(8):779-780. doi: 10.1038/s41563-019-0429-x. PubMed PMID: 31332317. View PDF
Qiao, E. L., Kumar, S., & Schaffer, D. v. (2019). Mastering their own fates through the matrix. Nature Materials 2019 18:8, 18(8), 779–780. https://doi.org/10.1038/s41563-019-0429-x. View PDF
Muckom R, McFarland S, Yang C, Perea B, Gentes M, Murugappan A, Tran E, Dordick JS, Clark DS, Schaffer DV. High-throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate. Biotechnol Bioeng. 2019 Jan; 116(1):193-205. doi: 10.1002/bit.26815. Epub 2018 Nov 6. PubMed PMID: 30102775; PubMed Central PMCID: PMC6289657. View PDF
Ekman, F. K., Ojala, D. S., Adil, M. M., Lopez, P. A., Schaffer, D. v., & Gaj, T. (2019). CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model. Molecular Therapy – Nucleic Acids, 17, 829–839. https://doi.org/10.1016/J.OMTN.2019.07.009. View PDF
Chen, S., Sun, S., Moonen, D., Lee, C., Lee, A. Y. F., Schaffer, D. v., & He, L. (2019). CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection. Cell Reports, 27(13), 3780-3789.e4. https://doi.org/10.1016/J.CELREP.2019.05.103. View PDF
Nierode GJ, Gopal S, Kwon P, Clark DS, Schaffer DV, Dordick JS. High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture. Biotechnol Bioeng. 2019 Jan; 116(1):168-180. doi: 10.1002/bit.26839. Epub 2018 Oct 27. PubMed PMID: 30229860; PubMed Central PMCID: PMC6289706. View PDF
Zimmermann, J. A., & Schaffer, D. v. (2019). Engineering biomaterials to control the neural differentiation of stem cells. Brain Research Bulletin, 150, 50–60. https://doi.org/10.1016/J.BRAINRESBULL.2019.05.007. View PDF
Barnes, C., Scheideler, O., & Schaffer, D. (2019). Engineering the AAV capsid to evade immune responses. Current Opinion in Biotechnology, 60, 99–103. https://doi.org/10.1016/J.COPBIO.2019.01.002. View PDF
Repina, N. A., Rosenbloom, A., Mukherjee, A., Schaffer, D. v., & Kane, R. S. (2017). “AT LIGHT SPEED: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior”. Annual Review of Chemical and Biomolecular Engineering, 8, 13. https://doi.org/10.1146/ANNUREV-CHEMBIOENG-060816-101254. View PDF
Gaj, T., Ojala, D. S., Ekman, F. K., Byrne, L. C., Limsirichai, P., & Schaffer, D. v. (2017). “In vivo genome editing improves motor function and extends survival in a mouse model of ALS”. Science Advances, 3(12). https://doi.org/10.1126/SCIADV.AAR3952/SUPPL_FILE/AAR3952_SM.PDF. View PDF
Kang, P. H., Kumar, S., & Schaffer, D. v. (2017a). “Making way for neural stemness”. Nature Materials 2017 16:12, 16(12), 1174–1176. https://doi.org/10.1038/nmat5043. View PDF
Mukherjee, A., Repina, N. A., Schaffer, D. v., & Kane, R. S. (2017). “Optogenetic tools for cell biological applications”. Journal of Thoracic Disease, 9(12), 4867. https://doi.org/10.21037/JTD.2017.11.73
Kang, P. H., Kumar, S., & Schaffer, D. v. (2017b). “Novel biomaterials to study neural stem cell mechanobiology and improve cell-replacement therapies”. Current Opinion in Biomedical Engineering, 4, 13–20. https://doi.org/10.1016/J.COBME.2017.09.005
Wooley, D. P., Sharma, P., Weinstein, J. R., Kotha Lakshmi Narayan, P., Schaffer, D. v., & Excoffon, K. J. D. A. (2017). “A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line”. Journal of Virological Methods, 250, 47–54. https://doi.org/10.1016/J.JVIROMET.2017.09.008
Sinn, P. L., Hwang, B. Y., Li, N., Ortiz, J. L. S., Shirazi, E., Parekh, K. R., Cooney, A. L., Schaffer, D. v., & McCray, P. B. (2017). “Novel GP64 envelope variants for improved delivery to human airway epithelial cells”. Gene Therapy 2017 24:10, 24(10), 674–679. https://doi.org/10.1038/gt.2017.78
Epstein, B. E., & Schaffer, D. v. (2017). “Combining engineered nucleases with adeno-associated viral vectors for therapeutic gene editing”. Advances in Experimental Medicine and Biology, 1016, 29–42. https://doi.org/10.1007/978-3-319-63904-8_2/TABLES/1
Bergen, J., & Schaffer, D. (2017). “4.33 Engineering Viruses For Gene Therapy”. Comprehensive Biomaterials II, 600–616. https://doi.org/10.1016/B978-0-08-100691-7.00167-1. View PDF
Rodrigues, G. M. C., Gaj, T., Adil, M. M., Wahba, J., Rao, A. T., Lorbeer, F. K., Kulkarni, R. U., Diogo, M. M., Cabral, J. M. S., Miller, E. W., Hockemeyer, D., & Schaffer, D. v. (2017). “Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System”. Stem Cell Reports, 8(6), 1770–1783. https://doi.org/10.1016/J.STEMCR.2017.04.027. View PDF
Sanghvi, J. C., Mai, D., Arkin, A. P., & Schaffer, D. v. (2017). A comprehensive stochastic computational model of HIV infection from DNA integration to viral burst. https://doi.org/10.48550/arxiv.1711.11270. View PDF
Schaffer, D., & Willerth, S. (2017). “5.8 Scaffold Materials for Human Embryonic Stem Cell Culture and Differentiation”. Comprehensive Biomaterials II, 129–153. https://doi.org/10.1016/B978-0-12-803581-8.10111-0. View PDF
Adil, M. M., Vazin, T., Ananthanarayanan, B., Rodrigues, G. M. C., Rao, A. T., Kulkarni, R. U., Miller, E. W., Kumar, S., & Schaffer, D. v. (2017). “Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons”. Biomaterials, 136, 1–11. https://doi.org/10.1016/J.BIOMATERIALS.2017.05.008. View PDF
Gaj, T., Staahl, B. T., Rodrigues, G. M. C., Limsirichai, P., Ekman, F. K., Doudna, J. A., & Schaffer, D. v. (2017). “Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery”. Nucleic Acids Research, 45(11), e98–e98. https://doi.org/10.1093/NAR/GKX154. View PDF
Adil, M. M., Rodrigues, G. M. C., Kulkarni, R. U., Rao, A. T., Chernavsky, N. E., Miller, E. W., & Schaffer, D. v. (2017). “Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform”. Scientific Reports 2017 7:1, 7(1), 1–11. https://doi.org/10.1038/srep40573. View PDF